Understanding the formulation variables of orodispersible tablets containing simvastatin solid dispersion using Box-Behnken design
نویسندگان
چکیده
منابع مشابه
Preparation and Evaluation of Orodispersible Tablets Containing Hydroxylbutyl-β-Cyclodextrin-Simvastatin Solid Dispersion
Purpose: To formulate simvastatin orodispersible tablets with high dissolution rate and enhanced bioavailability. Methods: Simvastatin solid dispersions in βcyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios by kneading and solvent evaporation methods. Compatibility was investigated by Differential scanning calorimetry (...
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ژورنال
عنوان ژورنال: Drugs and Therapy Studies
سال: 2012
ISSN: 2038-9507,2038-9493
DOI: 10.4081/dts.2012.e7